Category: Treatment

Treat these three conditions to avoid Alzheimer’s Disease.

Consult your medical provider for a comprehensive evaluation to identify which of the following conditions you have. Research recommends that early screening and treating any three of the conditions could prevent Alzheimer’s disease.

Consult your medical provider for a comprehensive evaluation to identify which of the following conditions you have. Research recommends that early screening and treating any three of the conditions could prevent or cure Alzheimer’s disease.

  1. Depression
    • Screen for depression using clinical assessments.
    • Treatment: Avoid selective serotonin reuptake inhibitors (SSRIs) due to their association with increased dementia risk. If needed, fluoxetine may be preferred as it increases TGF-β, which benefits neuroprotection.
  2. Diabetes and Insulin Resistance
    • Check fasting blood glucose and HbA1c levels.
    • Treatment: Optimize diabetes management with insulin or glucose-lowering medications. Consider intranasal insulin therapy to improve cerebral glucose metabolism.
  3. Dyslipidemia
    • Measure cholesterol and triglyceride levels.
    • Treatment: Use statins (lipophilic or hydrophilic) to reduce dementia risk.
  4. Hypertension
    • Monitor blood pressure regularly.
    • Treatment: Beta-blockers and diuretics are most effective in reducing dementia risk.
  5. Inflammation
    • Measure C-reactive protein (CRP) to detect systemic inflammation.
    • Treatment: NSAIDs (e.g., ibuprofen) may lower AD risk. Gut microbiome modulation (probiotics or antibiotics) can reduce neuroinflammation.
  6. Vascular Abnormalities
    • Screen for cerebrovascular disease (stroke history, carotid ultrasound, or MRI).
    • Treatment: Manage vascular health through antiplatelet therapy, lifestyle interventions, and hypertension control.
  7. Nutritional Deficiencies
    • Test for Vitamin D, folate, and niacin levels.
    • Treatment: Supplement with Vitamin D, folate, and a Mediterranean diet to slow cognitive decline.
  8. Mitochondrial Dysfunction
    • Assess for chronic fatigue and metabolic indicators.
    • Treatment: Lithium therapy can restore mitochondrial function. Valproate may enhance mitochondrial energy production.
  9. Transforming Growth Factor Beta (TGF-β) Deficiency
    • Measure TGF-β levels in plasma.
    • Treatment: Fluoxetine increases TGF-β and may aid in neuronal repair.
  10. Wnt/β-Catenin Deficiency
    • Screen for cognitive decline progression.
    • Treatment: Doxycycline therapy has been shown to increase Wnt signaling and enhance neuroprotection.
  11. Metabolic Syndrome
    • Identify obesity, insulin resistance, and hypertension.
    • Treatment: Address hypertriglyceridemia, high waist circumference, and hypertension.
  12. Circadian Rhythm Disturbances
    • Assess sleep patterns and actigraphy data.
    • Treatment: Melatonin therapy, bright light exposure, and photobiomodulation therapy (near-infrared light therapy) can improve circadian function and cognitive health.
  13. Underweight and Malnutrition
    • Monitor BMI and dietary intake.
    • Treatment: Increase caloric intake, protein-rich diets, and short-chain fatty acid (SCFA) supplementation to promote neuroprotection.

Sources of research evidence:

  1. Fessel J. Formulating Treatment to Cure Alzheimer’s Dementia: Approach . Int J Mol Sci. 2024;25(6):3524. doi:10.3390/ijms25063524.
  1. Livingston G, Huntley J, Sommerlad A, et al. Dementia prevention, intervention, and care: 2020 report of the Lancet Commission. Lancet. 2020;396(10248):413-446. doi:10.1016/S0140-6736(20)30367-6.
    • Supports multimodal interventions, including vascular risk factor management, lifestyle modifications, and cognitive training in preventing and reversing cognitive decline.
  2. Cummings J, Lee G, Nahed P, et al. Alzheimer’s disease drug development pipeline: 2022. Alzheimers Dement (N Y). 2022;8(1):e12295. doi:10.1002/trc2.12295.
    • Discusses the failure of single-drug approaches in AD treatment and the need for personalized medicine, aligning with Fessel’s multimodal approach.
  3. Jack CR Jr, Bennett DA, Blennow K, et al. NIA-AA research framework: Toward a biological definition of Alzheimer’s disease. Alzheimers Dement. 2018;14(4):535-562. doi:10.1016/j.jalz.2018.02.018.
    • Provides evidence that Alzheimer’s pathology is driven by multiple interacting factors, necessitating individualized treatment strategies.
  4. Espeland MA, Rapp SR, Manson JE, et al. Long-term effects of lifestyle interventions to prevent diabetes on cognitive function: Action for Health in Diabetes study. J Am Geriatr Soc. 2021;69(3):698-708. doi:10.1111/jgs.16948.
    • Demonstrates that aggressive diabetes management improves cognitive function, supporting the inclusion of diabetes treatment in AD intervention strategies.
  5. Walker KA, Gottesman RF, Wu A, et al. Systemic inflammation during midlife and cognitive change over 20 years: The ARIC Study. Neurology. 2019;92(11):e1256-e1267. doi:10.1212/WNL.0000000000007094.
    • Confirms the role of inflammation in cognitive decline and supports the recommendation to target systemic inflammation as part of a curative strategy for AD.
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The Role of Physical Exercise in Alzheimer’s Management

Physical exercise is not only beneficial for general health but also plays a significant role in managing Alzheimer’s disease. Regular activity can improve mood, reduce anxiety, and potentially slow cognitive decline. Simple exercises like walking, stretching, or chair yoga are excellent for patients at various stages of Alzheimer’s. Tailor activities to their abilities—even light gardening or dancing can foster engagement and joy.

Caregivers should aim for consistency, integrating exercise into the daily routine to provide structure and reduce confusion. Social forms of exercise, like group walking sessions, also encourage interaction, which is essential for emotional well-being. Safety is paramount—ensure that the environment is secure and monitor the patient to avoid overexertion.

For additional guidance and ideas, consider the following resources:

  • National Institute on Aging: Explore their comprehensive guide to safe and effective exercises for older adults, including Alzheimer’s patients. Visit nia.nih.gov/health/exercise-physical-activity.
  • Go4Life Program: Developed by the National Institute on Aging, this program offers free videos, tips, and guides for incorporating exercise into daily life. Access it at go4life.nia.nih.gov.
  • Alzheimer’s Society (UK): Provides a list of exercise activities tailored for people living with dementia. Learn more at alzheimers.org.uk.
  • YouTube Exercise Channels: Channels like “Chair Yoga with Adriene” or “Eldergym Senior Fitness” offer free, easy-to-follow exercise routines.
  • Local YMCA or Senior Centers: Many offer specialized fitness programs designed for cognitive and physical wellness. Contact your local center for availability.

Incorporating regular physical activity into the care plan not only benefits patients but also provides caregivers with opportunities to engage positively with their loved ones.

Supporting Patients and Families Navigating Alzheimer’s Disease

Caring for a loved one with Alzheimer’s disease can be both challenging and rewarding. For caregivers, understanding the disease’s progression is vital. Early-stage Alzheimer’s may present as mild memory lapses, but as it advances, patients often require more intensive support. Families should prioritize creating a structured environment with clear routines to reduce confusion. Labeling items, maintaining a daily schedule, and incorporating visual cues can help patients navigate their surroundings more independently. Encouraging regular physical activity and a balanced diet also supports overall health and may help mitigate disease progression.

Behavioral health challenges, such as agitation or depression, are common in Alzheimer’s patients and can be stressful for caregivers. To manage these behaviors, families should focus on identifying potential triggers. Often, changes in routine, overstimulation, or unmet needs (like hunger or discomfort) can lead to behavioral changes. Responding with patience and empathy is crucial—arguing or correcting the patient can exacerbate the situation. Instead, redirecting their attention to a calming activity, such as listening to music or engaging in art, can help. Additionally, caregivers should not hesitate to seek professional guidance from behavioral health specialists when needed.

Supporting caregivers themselves is just as important as caring for the patient. Burnout and stress can take a toll on physical and mental health. Families should explore respite care services and community resources like Alzheimer’s support groups to share experiences and solutions. Ensuring caregivers have time for self-care—whether through exercise, hobbies, or simply resting—is essential to sustaining their ability to provide quality care. Below are some helpful resources:

  • Alzheimer’s Association: Provides education, support groups, and a 24/7 helpline (1-800-272-3900). Visit alz.org for more information.
  • National Institute on Aging: Offers comprehensive information on Alzheimer’s research, caregiving tips, and safety. Access their resources at nia.nih.gov/health/alzheimers.
  • Family Caregiver Alliance: A resource hub for caregiving strategies, policy updates, and support. Learn more at caregiver.org.
  • Eldercare Locator: Connects families with local services, such as respite care and adult day programs. Use their service at eldercare.acl.gov.
  • Music & Memory: A program that helps improve quality of life through personalized music playlists. Find out more at musicandmemory.org.
  • “10 Warning Signs of Alzheimer’s” Video: Watch this informative video on recognizing early signs on the Alzheimer’s Association’s YouTube Channel.
  • Teepa Snow’s Positive Approach to Care: Explore practical caregiving techniques and strategies on her YouTube Channel.
  • Dementia Care Resources: Access free videos and guides from Dementia Care Central at dementiacarecentral.com.
  • Alzheimer’s Research Updates: Stay informed with the latest studies at alzforum.org.

Alzheimer’s is a journey for both patients and their families, but with the right strategies and support systems, it is possible to navigate this path with resilience and compassion.

The value I provide with my expertise in behavioral health.

I am Dr. Sylvester Orimaye, PhD, MPH. DBH-C. As the Founder and Director of the Behavioral Health Outcomes and Artificial Intelligence Laboratory, I wanted to briefly overview what I do in behavioral health. As a data scientist and behavioral health researcher, I am particularly interested in early screening of behavioral health problems so patients can access timely interventions before their illnesses get severe. This process can potentially save substantial healthcare costs and decrease the need for emergency room visits or hospitalization.

More importantly, I am using my expertise in Artificial Intelligence to create screening technologies that guarantee accuracy and effectiveness in identifying behavioral health problems. This idea will revolutionize the way we diagnose and treat behavioral health problems.

Finally, as a researcher and someone with expertise in behavioral health, I intend to contribute to and enhance patient-centered care, manage population health, improve reporting, and support value-based payments in healthcare and community-based services for individuals with behavioral health disorders, particularly those with depression, mild cognitive impairment, and Alzheimer’s disease.

Patient Care and Implicit Biases

Suppose you have ever attempted the Harvard Implicit Association Test (IAT). In that case, you will realize it shows implicit biases or an unexpected inclination towards a particular category of interest that may often contradict your beliefs or expectations. Nevertheless, the IAT emerged as a valuable instrument for unearthing unconscious biases that may not align with our convictions.

Navigating through professional responsibilities laden with ethical considerations, I have always been vigilant about addressing both conscious and unconscious biases. However, the IAT underscored the intricate nature of these biases, penetrating even the subconscious layers of our attitudes. Implicit attitudes towards race/ethnicity, disability, gender, age, sexual orientation, national origin, veteran status, obesity, addiction, and homelessness can significantly influence clinical judgment. The intricacies and limitations in understanding these multifaceted factors often contribute to these biases, highlighting the need for continued introspection.

In healthcare, where the stakes are high, and patient well-being is paramount, acknowledging the influence of implicit biases becomes a critical aspect of delivering equitable and patient-centered care. Understanding that these biases impact clinical judgment necessitates a nuanced approach to patient interactions. It calls for recognizing patients’ diverse backgrounds, experiences, and identities in healthcare.


The path forward lies in fostering a healthcare environment where patients are treated as care recipients and active contributors to their well-being. Contextualizing care, active listening, and involving patients in decision-making become indispensable practices in mitigating the impact of implicit biases. Education emerges as a key catalyst for change, equipping healthcare professionals with the knowledge and awareness needed to navigate the complex landscape of human diversity.

As we strive for positive health outcomes, we must view patient care as a collaborative effort, transcending the boundaries of bias. The journey toward unbiased healthcare is ongoing, requiring commitment, self-reflection, and a collective dedication to dismantling ingrained prejudices. By embracing this ethos, we can pave the way for a healthcare system that not only recognizes the existence of implicit biases but actively works towards mitigating their impact to improve patient well-being.

You can take the Harvard Implicit Association Test here.

Medicare Agrees to Cover PET Scans: Great News for Diagnosis and Treatment of Alzheimer’s Disease.

The Centers for Medicare and Medicaid Services (CMS) have recently announced a significant expansion in Medicare coverage for amyloid Positron Emission Tomography (PET) scans for diagnosing Alzheimer’s disease, which is set to take effect in 2024.

This is a significant development in medical imaging technology, particularly PET scans, which have opened new avenues for understanding and managing Alzheimer’s disease. PET scans are a crucial tool in diagnosing Alzheimer’s, as they provide detailed images of the brain’s activity and abnormalities. In particular, Florbetapir, a tracer used in PET imaging for Alzheimer’s, binds to beta-amyloid plaques. A small amount of this tracer is injected into the patient’s bloodstream during a PET scan. As it travels to the brain, the PET scanner detects the emitted positrons, creating a detailed map of beta-amyloid plaque distribution. This imaging technique enables physicians to visualize and quantify the presence of beta-amyloid plaques, aiding in the early detection of Alzheimer’s disease.

Early diagnosis is essential as it helps implement appropriate interventions, including lifestyle changes, medication, and support for patients and their families. Moreover, PET scans also play a crucial role in guiding treatment strategies for Alzheimer’s patients. By providing a comprehensive understanding of the disease’s progression and severity, PET imaging assists healthcare professionals in tailoring personalized treatment plans. With the expansion of Medicare coverage for amyloid PET scans, more patients will have access to this diagnostic tool, leading to early detection and better management of Alzheimer’s disease. This is a significant step made by the CMS in Alzheimer’s research. It paves way for better better patient care and improved outcomes in the future.