Tag: Dementia

Treat these three conditions to avoid Alzheimer’s Disease.

Consult your medical provider for a comprehensive evaluation to identify which of the following conditions you have. Research recommends that early screening and treating any three of the conditions could prevent Alzheimer’s disease.

Consult your medical provider for a comprehensive evaluation to identify which of the following conditions you have. Research recommends that early screening and treating any three of the conditions could prevent or cure Alzheimer’s disease.

  1. Depression
    • Screen for depression using clinical assessments.
    • Treatment: Avoid selective serotonin reuptake inhibitors (SSRIs) due to their association with increased dementia risk. If needed, fluoxetine may be preferred as it increases TGF-β, which benefits neuroprotection.
  2. Diabetes and Insulin Resistance
    • Check fasting blood glucose and HbA1c levels.
    • Treatment: Optimize diabetes management with insulin or glucose-lowering medications. Consider intranasal insulin therapy to improve cerebral glucose metabolism.
  3. Dyslipidemia
    • Measure cholesterol and triglyceride levels.
    • Treatment: Use statins (lipophilic or hydrophilic) to reduce dementia risk.
  4. Hypertension
    • Monitor blood pressure regularly.
    • Treatment: Beta-blockers and diuretics are most effective in reducing dementia risk.
  5. Inflammation
    • Measure C-reactive protein (CRP) to detect systemic inflammation.
    • Treatment: NSAIDs (e.g., ibuprofen) may lower AD risk. Gut microbiome modulation (probiotics or antibiotics) can reduce neuroinflammation.
  6. Vascular Abnormalities
    • Screen for cerebrovascular disease (stroke history, carotid ultrasound, or MRI).
    • Treatment: Manage vascular health through antiplatelet therapy, lifestyle interventions, and hypertension control.
  7. Nutritional Deficiencies
    • Test for Vitamin D, folate, and niacin levels.
    • Treatment: Supplement with Vitamin D, folate, and a Mediterranean diet to slow cognitive decline.
  8. Mitochondrial Dysfunction
    • Assess for chronic fatigue and metabolic indicators.
    • Treatment: Lithium therapy can restore mitochondrial function. Valproate may enhance mitochondrial energy production.
  9. Transforming Growth Factor Beta (TGF-β) Deficiency
    • Measure TGF-β levels in plasma.
    • Treatment: Fluoxetine increases TGF-β and may aid in neuronal repair.
  10. Wnt/β-Catenin Deficiency
    • Screen for cognitive decline progression.
    • Treatment: Doxycycline therapy has been shown to increase Wnt signaling and enhance neuroprotection.
  11. Metabolic Syndrome
    • Identify obesity, insulin resistance, and hypertension.
    • Treatment: Address hypertriglyceridemia, high waist circumference, and hypertension.
  12. Circadian Rhythm Disturbances
    • Assess sleep patterns and actigraphy data.
    • Treatment: Melatonin therapy, bright light exposure, and photobiomodulation therapy (near-infrared light therapy) can improve circadian function and cognitive health.
  13. Underweight and Malnutrition
    • Monitor BMI and dietary intake.
    • Treatment: Increase caloric intake, protein-rich diets, and short-chain fatty acid (SCFA) supplementation to promote neuroprotection.

Sources of research evidence:

  1. Fessel J. Formulating Treatment to Cure Alzheimer’s Dementia: Approach . Int J Mol Sci. 2024;25(6):3524. doi:10.3390/ijms25063524.
  1. Livingston G, Huntley J, Sommerlad A, et al. Dementia prevention, intervention, and care: 2020 report of the Lancet Commission. Lancet. 2020;396(10248):413-446. doi:10.1016/S0140-6736(20)30367-6.
    • Supports multimodal interventions, including vascular risk factor management, lifestyle modifications, and cognitive training in preventing and reversing cognitive decline.
  2. Cummings J, Lee G, Nahed P, et al. Alzheimer’s disease drug development pipeline: 2022. Alzheimers Dement (N Y). 2022;8(1):e12295. doi:10.1002/trc2.12295.
    • Discusses the failure of single-drug approaches in AD treatment and the need for personalized medicine, aligning with Fessel’s multimodal approach.
  3. Jack CR Jr, Bennett DA, Blennow K, et al. NIA-AA research framework: Toward a biological definition of Alzheimer’s disease. Alzheimers Dement. 2018;14(4):535-562. doi:10.1016/j.jalz.2018.02.018.
    • Provides evidence that Alzheimer’s pathology is driven by multiple interacting factors, necessitating individualized treatment strategies.
  4. Espeland MA, Rapp SR, Manson JE, et al. Long-term effects of lifestyle interventions to prevent diabetes on cognitive function: Action for Health in Diabetes study. J Am Geriatr Soc. 2021;69(3):698-708. doi:10.1111/jgs.16948.
    • Demonstrates that aggressive diabetes management improves cognitive function, supporting the inclusion of diabetes treatment in AD intervention strategies.
  5. Walker KA, Gottesman RF, Wu A, et al. Systemic inflammation during midlife and cognitive change over 20 years: The ARIC Study. Neurology. 2019;92(11):e1256-e1267. doi:10.1212/WNL.0000000000007094.
    • Confirms the role of inflammation in cognitive decline and supports the recommendation to target systemic inflammation as part of a curative strategy for AD.
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The Role of Physical Exercise in Alzheimer’s Management

Physical exercise is not only beneficial for general health but also plays a significant role in managing Alzheimer’s disease. Regular activity can improve mood, reduce anxiety, and potentially slow cognitive decline. Simple exercises like walking, stretching, or chair yoga are excellent for patients at various stages of Alzheimer’s. Tailor activities to their abilities—even light gardening or dancing can foster engagement and joy.

Caregivers should aim for consistency, integrating exercise into the daily routine to provide structure and reduce confusion. Social forms of exercise, like group walking sessions, also encourage interaction, which is essential for emotional well-being. Safety is paramount—ensure that the environment is secure and monitor the patient to avoid overexertion.

For additional guidance and ideas, consider the following resources:

  • National Institute on Aging: Explore their comprehensive guide to safe and effective exercises for older adults, including Alzheimer’s patients. Visit nia.nih.gov/health/exercise-physical-activity.
  • Go4Life Program: Developed by the National Institute on Aging, this program offers free videos, tips, and guides for incorporating exercise into daily life. Access it at go4life.nia.nih.gov.
  • Alzheimer’s Society (UK): Provides a list of exercise activities tailored for people living with dementia. Learn more at alzheimers.org.uk.
  • YouTube Exercise Channels: Channels like “Chair Yoga with Adriene” or “Eldergym Senior Fitness” offer free, easy-to-follow exercise routines.
  • Local YMCA or Senior Centers: Many offer specialized fitness programs designed for cognitive and physical wellness. Contact your local center for availability.

Incorporating regular physical activity into the care plan not only benefits patients but also provides caregivers with opportunities to engage positively with their loved ones.

Supporting Patients and Families Navigating Alzheimer’s Disease

Caring for a loved one with Alzheimer’s disease can be both challenging and rewarding. For caregivers, understanding the disease’s progression is vital. Early-stage Alzheimer’s may present as mild memory lapses, but as it advances, patients often require more intensive support. Families should prioritize creating a structured environment with clear routines to reduce confusion. Labeling items, maintaining a daily schedule, and incorporating visual cues can help patients navigate their surroundings more independently. Encouraging regular physical activity and a balanced diet also supports overall health and may help mitigate disease progression.

Behavioral health challenges, such as agitation or depression, are common in Alzheimer’s patients and can be stressful for caregivers. To manage these behaviors, families should focus on identifying potential triggers. Often, changes in routine, overstimulation, or unmet needs (like hunger or discomfort) can lead to behavioral changes. Responding with patience and empathy is crucial—arguing or correcting the patient can exacerbate the situation. Instead, redirecting their attention to a calming activity, such as listening to music or engaging in art, can help. Additionally, caregivers should not hesitate to seek professional guidance from behavioral health specialists when needed.

Supporting caregivers themselves is just as important as caring for the patient. Burnout and stress can take a toll on physical and mental health. Families should explore respite care services and community resources like Alzheimer’s support groups to share experiences and solutions. Ensuring caregivers have time for self-care—whether through exercise, hobbies, or simply resting—is essential to sustaining their ability to provide quality care. Below are some helpful resources:

  • Alzheimer’s Association: Provides education, support groups, and a 24/7 helpline (1-800-272-3900). Visit alz.org for more information.
  • National Institute on Aging: Offers comprehensive information on Alzheimer’s research, caregiving tips, and safety. Access their resources at nia.nih.gov/health/alzheimers.
  • Family Caregiver Alliance: A resource hub for caregiving strategies, policy updates, and support. Learn more at caregiver.org.
  • Eldercare Locator: Connects families with local services, such as respite care and adult day programs. Use their service at eldercare.acl.gov.
  • Music & Memory: A program that helps improve quality of life through personalized music playlists. Find out more at musicandmemory.org.
  • “10 Warning Signs of Alzheimer’s” Video: Watch this informative video on recognizing early signs on the Alzheimer’s Association’s YouTube Channel.
  • Teepa Snow’s Positive Approach to Care: Explore practical caregiving techniques and strategies on her YouTube Channel.
  • Dementia Care Resources: Access free videos and guides from Dementia Care Central at dementiacarecentral.com.
  • Alzheimer’s Research Updates: Stay informed with the latest studies at alzforum.org.

Alzheimer’s is a journey for both patients and their families, but with the right strategies and support systems, it is possible to navigate this path with resilience and compassion.

Adverse Childhood Experiences and Alzheimer’s Disease

Understanding the Link between ACEs and Alzheimer's Disease
ACEs-AD-FullDownload

Ten Useful Learning Resources on Alzheimer’s Disease

Below is a list of useful resources on Alzheimer’s Disease:

1. What is Alzheimer’s Disease?: https://www.alz.org/alzheimers-dementia/what-is-alzheimers   

2. On the path to 2025: understanding the Alzheimer’s disease continuum: https://pubmed.ncbi.nlm.nih.gov/28793924/

3. Breaking the Alzheimer’s Dementia continuum with Evidence-Based Research: https://alzheimerscontinuum.com/

4. Finding Dementia Care and Local Services: https://www.alzheimers.gov/life-with-dementia/find-local-services 

5. NIH Toolbox: https://www.healthmeasures.net/explore-measurement-systems/nih-toolbox

6. Alzheimer’s and Related Dementias Resources for Professionals: https://www.nia.nih.gov/health/health-care-professionals-information/alzheimers-and-related-dementias-resources

7. Alzheimer’s Disease: Resources for Patients and Families

https://www.ohsu.edu/brain-institute/alzheimers-disease-resources-patients-and-families

8. Trauma Resources for Families: https://www.aap.org/en/patient-care/trauma-informed-care/resources-for-families/

9. Coping With Traumatic Events: https://www.nimh.nih.gov/health/topics/coping-with-traumatic-events

10. Trauma Resource Institute: https://www.traumaresourceinstitute.com/

Deterioration in language can predict early symptoms of Alzheimer’s Dementia.

In a recent study, an independent linguistic battery comprising only the language components or subtests of popular neuropsychological batteries showed a better clinical detection for MCI-AD than using an exhaustive battery of test.

Mild Cognitive Impairment due to Alzheimer’s disease (MCI-AD) is a precursor to Alzheimer’s disease (AD). It is characterized by a cognitive decline usually associated with aging or AD. However, some of the profound characteristics of MCI-AD are the gradual degrading of cognitive speech functions, which is often affected long before the diagnosis of MCI-AD. Research has shown that neurodegenerative disease such as MCI-AD deteriorates nerve cells that control cognitive speech and language processes, affecting an individual’s ability to make effective verbal utterances. As a result, the need for early detection of MCI-AD using linguistic biomarkers has grown. However, it is still prevalent to diagnose MCI-AD utilizing a combination of neuropsychological batteries and a doctor’s longitudinal observation of the individual. In a recent study, an independent linguistic battery comprising only the language components or subtests of popular neuropsychological batteries showed a better clinical detection for MCI-AD than using an exhaustive battery of tests. As confirmed by the study, the figures below compare the underlying patterns of the linguistic components and risk factors of MCI-AD and healthy control groups.

What is the Alzheimer’s Dementia Continuum?

…several findings suggest a possible reversal of AD-type MCI with carefully administered behavioral therapy, including brain-stimulating exercises.

Alzheimer’s disease (AD) is the prodromal stage of Dementia. Imagine the disease as a continuum, beginning with Mild Cognitive Impairment (MCI) to possible/probable AD, and ultimately Dementia, the end-stage. Not all healthy people will have MCI, and not all MCI will result in AD. However, there is research evidence that a substantial proportion of people with AD-type MCI will progress to AD and subsequently Dementia. On the other hand, several findings suggest a possible reversal of AD-type MCI with carefully administered behavioral therapy, including brain-stimulating exercises. In addition to a good diet (the Mediterranean diet preferred), a minimum of 30 minutes of daily exercise, social connectedness (community groups, family, friends), and brain-stimulating exercises have been associated with possible reversal or delay of AD-type Dementia.

The figure below gives a clear overview of the Alzheimer’s disease Dementia continuum.

Overview of Alzheimer’s disease Dementia continuum. Image source: https://www.alz.org/

Below, I provide a list of websites where you can try out different brain-stimulating exercises:

BRAINGLE: Braingle is a place to solve puzzles, brush up on your trivia, play games and give your brain a workout.

brainHQ: American Association of Retired Persons (AARP) brain training exercise.

JigZone: Online Jigsaw Puzzles

Lumosity: Personalized brain training.

WholisticResearch: Brain exercises to improve cognitive performance and memory retention.

For additional information on Alzheimer’s disease and Dementia, visit https://www.alz.org/.

There is hope, even when your brain tells you there isn’t.

John Green